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HVMN Ketone — The world's first and only ketone ester
HVMN Ketone is a clinically validated superfuel that can be used to improve training, recovery, and performance.
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@syswarren In my understanding, exogenous ketone supplements are shortcuts to raise the blood ketone levels without nutritional ketosis. That means that you can still eat carbs and get the benefits of ketones to some extent.
(Source: Dom D'Agostino said it in a podcast.)
@syswarren yes, this is one of my personal favorite use cases! The transition into ketosis is tough because your brain and body has low glucose (from fasting or carb restriction) and has low ketones (ketone production has picked up yet). Drinking HVMN Ketone will bridge that gap of energy availability and make the transition into ketosis or a longer fast much more smoothly.
@syswarren Yes, whilst taking ketone supplements doesn't help your body to make ketones, it will help to alleviate the nasty symptoms of ketone adaptation. Plus being a great source of energy for people who want more energy to work out whilst on a keto diet.
@syswarren Entering ketosis is not a challenge if you have adequate electrolytes. No headaches or side effects.
I've known HVMN since it was called Nootrobox, a Nootropics company. With the rebranding to HVMN and the launch of HVMN Ketone, it's incredibly exciting to see the company evolve to now become an important pillar of the human performance and biohacking community. The research behind ketosis is very compelling, and I'm really excited to see how HVMN Ketone will impact people's productivity and health.
@hnshah thank you for the longtime support ! Excited to finally unveil this to the world. I’ll be online tomorrow morning with my team including our Research Lead Dr. @briannastubbs to answer any and all questions on the science, technology, and data.
From @DerekLowe, a medicinal chemist of 30+ years:
First thought is that this invites FDA scrutiny, but I'm sure they're invoking the "dietary supplement" loophole, which is a mile wide (1/x)
Also, this appears to be an ester of beta-hydroxybutyric acid. What's the alcohol? Presumably ethyl? Is this like doing a shot? (2/x)
Next, ketone bodies like this are indeed a natural part of metabolism. But taking 25g at a gulp is something else again. (3/x)
Would very much like to know what toxicity testing has been done. Long-term liver effects, etc., possible? This is medicine, not food. (4/4)
https://twitter.com/datarade/sta...
@dereklowe @datarade
My responses on Twitter copied below:
(1) Incorrect. HVMN Ketone is a food and has a nutrition label. Our partners at Oxford went through FDA GRAS process: https://www.accessdata.fda.gov/s...
(2) The alcohol component is (R)-1,3 butanediol, a common food additive, which is rapidly converted into D-BHB.
(3) Per your toxicity question, many kinetic and safety studies done on both animal and human subjects. Hence, FDA GRAS as a foodstuff.
(4) Happy to discuss data and work in detail. Copying my colleague Dr. @BriannaStubbs, who ran a number of the human studies at Oxford.
I’m all for it. I’ve been working closely with the founder of Waggle Foods, whose pioneering a ketogenic diet for sick animals, of course with human-grade ingredients. Why is HVMN the next penicillin? Also, could you please clearly list your ingredients? If it contains any sugars, for example, it defeats the whole purpose. I’m also one not buy without knowing the ingredients.
Congrats @geoffreywoo @bdm_tastemakers @briannastubbs on the launch! Learned a little bit about ketones from Michael during a long run and am super excited to try this out as a new fuel source!
@geoffreywoo @briannastubbs @dtran320 Thanks David! Excited for you to try. Let's hit the trails again soon, that was a great 15mi run!
@geoffreywoo @bdm_tastemakers @dtran320 Thanks David, hope I can join you next time and be fueled by HVMN Ketone!
This is interesting but I think they have to be very careful about how it is marketed, because "Keto" seems to be very misunderstood and a bit of a buzzword.
Consider this a specialized supplement for ELITE athletes to increase performance and endurance. Curious if this would even be considered doping in the sports world. While it may be the best ketone supplement on the market, it doesn't mean that any of you need ketone supplementation at all. Expensive, too.
Maybe some day your doctor will prescribe this to you for the therapeutic effects of ketones, but again that's a specialized use.
For 99.99% of the population, either take caffeine/pre-workout/creatine or try ketosis through dietary carbohydrate restriction (Keto diet).
I lift, and I'm not interested. However, Keto diet itself can be great for fat loss and cutting, or as a long term diet. This supplement is not going to help you lose fat from obesity and inactivity.
My question is whether you created/researched this ester yourself or if you are just licensing it from TΔS?
This is the GRAS exemption filed by TΔS https://www.fda.gov/downloads/Fo...
"TΔS intends to use D-β-hydroxybutyrate ester in beverages, bars, and gels. The ketone ester was generally well tolerated, although some gastrointestinal effects were reported at the highest dose tested. The taste of D-β-hydroxybutyrate ester is bitter and sharp." All interesting to know about this compound.
@tombielecki Yes, HVMN Ketone contains ΔG from TΔS (the Univ. of Oxford technology transfer company). They're a phenomenal partner, and we're the exclusive commercialization partner. The ester is covered by a family of patents, so in effect, HVMN Ketone is the one and only ketone ester drink out there.
@tombielecki Thanks for sharing! Yes, FDA recognizes HVMN Ketone as a generally regarded as safe food. To your other point - the flavor was admittedly acrid back in the early production samples, but we've taken a couple measures to mitigate. First, the production ketone is pure ketone ester, eliminating the foul-tasting anomalies of the early pre-production batches. On top of that, we put significant R&D into optimizing flavor & preserving freshness, and are happy with where things landed! The taste still does have a bitter kick to it, but nothing too crazy.
@geoffreywoo Can you talk a little about pricing? Are there plans on lowering the price in the future? $99.00 for a day worth of this product is definitely out of many people's price range. (https://help.hvmn.com/hvmn-keton...)
@karlnislow we desperately understand that. Scaling a novel process is extremely expensive and tough. We have a roadmap to bring costs down to as cheap and accessible as possible: https://hvmn.com/blog/introducin...
@geoffreywoo @karlnislow Hi Karl! While the max is 3 per day, you certainly don't need to take 3 in a day, or take it on daily basis, for benefit. We say it's "for the days you need it most" -- so for some people that means everyday, others that means when they run their next marathon, etc.
@geoffreywoo @bdm_tastemakers Awesome! I'm glad you guys are already thinking about this and I realize it must have been an undertaking. Good luck with the launch. Excited to try the goods.
@nivo0o0 of course ! Come on over to our HQ. Let’s test both your blood glucose and blood ketone levels before and after to see how HVMN Ketone immediately affects those 2 biomarkers
@kkdub Ketone salts elevate ketones to about 0.3 - 1 mM BHB. As salt is a carrier, ketone salts have quite a high salt load (80+% RDA of sodium in a single serving) which triggers GI distress for some users.
The BHB ketone ester raises ketones between 3-5 mM BHB. This is equivalent to 7-10 days of fasting worth of ketones. Diving one step further, if you look at the scientific literature, all the performance benefits of exogenous ketones were actually done by our research partners at the University of Oxford and NIH on our specific ketone ester in HVMN Ketone. In fact, emerging published data on ketone salts are showing that there's limited evidence for salts for athletic performance.
In short, the evidence to date suggests that our ketone ester in HVMN Ketone is the real deal. Our Research Lead Dr. @BriannaStubbs recently published a paper investigating the kinetics of both salt and ester here if you'd like to see a formal whitepaper and discussion: https://www.frontiersin.org/arti...
I've been pushing myself to regain my fitness using the indoor rowing machine and would be very keen to try this out to see if it has any discernable performance improvements (UK based). Also would be eager to find out if this passes current WADA doping laws, particularly in the context of competing in the British indoor rowing championships next month.
@erickbarron86 I️ know and it’s part of the scaling operation of a novel process. We have a roadmap to scale this to be as cheap and accessible as possible: https://hvmn.com/blog/introducin...
@erickbarron86 Erick, you can take one bottle per day, but you certainly don't have to! HVMN Ketone is designed to be used "as needed" for the big days you need it.
@erickbarron86 @bdm_tastemakers would love to see a bit more info on dosage!
The website says a single serving is 25 grams, thats $22-33 per serving!
Whats a realistic dosage for the main use cases?
Would you do a full 25g before every workout?
To kick start a keto diet, would you just take full doses it for 3 days straight and then supplement with smaller amounts from there?
The makers describe this as a "Ketone Ester" compared to existing "Ketone Salt" products. This study, published Oct 30, describes their similarities and differences - the conclusion is a good one:
"In conclusion, drinks containing exogenous ketones, in either ester or salt form, can raise concentrations of blood βHB in humans, although elevation of L-βHB lasts longer after racemic KS consumption. Both KE and KS drinks mildly altered acid-base balance. Exogenous ketones lowered blood glucose and lipids without inhibiting endogenous insulin secretion. The KE delivered highly repeatable blood concentrations of D-βHB, although ketosis was decreased by a meal. Uptake and elimination of D-βHB were similar when several drinks were consumed in succession. The dietary KE could maintain ketosis using drinks taken regularly around a normal meal pattern, or using a continuous infusion via a nasogastric tube. Therefore, ketone drinks are a viable and practical alternative to dietary strategies to achieve ketosis."
https://www.frontiersin.org/arti...
@thom_ivy yes, authored by our very own research lead Dr. @briannastubbs !
@_selcukahmet Our research partners at Oxford and NIH have done extensive animal and human studies and we went through the FDA GRAS process to demonstrate the safety of HVMN Ketone as a foodstuff. This is a nutrient that's safe and has much more data than many food additives in our food supply today.
I want to buy all your stuff but I live in the UK. Help a brother out! The shipping basically doubles the price. Any tips ideas?
I have no idea about the quality of this product or company, but a simple google for "Ketone Ester" finds several other competitors. Specifically the work of Dom D'agostino in the Ketogenic diet space and Patrick Arnold of the Ketogenic supplement space, both have/endorsed products that are essentially the same as this.
Again, no judge of quality of the product or company, but when the tagline says "first and only" and its neither, it raises a red flag.
@tvventythree that’s incorrect. You’re seeing exogenous ketones made of ketone salts or MCT oil. HVMN Ketone is a ketone ester, and it’s the world’s first ketone ester that’s FDA GRAS as a foodstuff (not a supplement). I️ actually taped a conversation with Prof. Dom D’agostino this past weekend about the first commercial availability of a ketone ester, and we’ll be posting that discussion later this week / next week.
@geoffreywoo Thats terrific news and reassuring. Thanks for following up and addressing concerns! Looking forward to the discussion with Dom.
Am I right in assuming that a user of this product would only benefit from it if they were eating well and low carb? So it's an enhancer, not a quick fix - right?
Looks interesting. Would love to try once you start shipping to more countries.
Nice video btw!
@moinism thanks! Follow on tw or join our email list for updates in that dept 😉
Awesome, I will have to try this out. I am currently using the Pruvit KETO OS stuff, and it works well, especially when you maintain a nutritional ketosis. Flavor will be key!
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