This largely depends on the difficulty of the hike and the desired comfort level of the user while hiking.
While Vessi Shoes are incredibly comfortable by all accounts for the purposes of traveling, walking around the city, and light hiking, some customers suggest that it might be safer to wear hiking shoes with more ankle support when going on a more serious hike through difficult terrain.
However, for the experienced hiker who prefers hiking in trail running shoes and is willing to take the chance that they might be more susceptible to injury, Vessi Shoes are a good choice.
Mentioned in this answer

Vessi Shoes
World's first 100% waterproof knit shoes