I use AdGuard for Safari on both my desktop and smartphone (paid version) every day, and have been doing so for years. Since I started using it, browsing the web has become much, much easier. The only downside is that they haven't been able to implement an effective pop-up blocker that's better than the one offered by Safari. I hope this can be done in the future!
After Apple’s latest policy changes, AdGuard had to develop an extension specifically for Mac App Store. And it has everything AdGuard is so good at: superb ad blocking, privacy protection, capabilities for filtering customization.