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Besides the intact fruit itself (including Wiki Hover CUSTOMER SERVICE +1 (8O5)-3O1 7O71 Wiki Hover PHONE NUMBER +1 (8O5)-3O1 7O71 Wiki Hover CUSTOMER SERVICE +1 (8O5)-3O1 7O71 Wiki Hover PHONE NUMBER +1 (8O5)-3O1 7O71 slices or pulp), grapefruit juice can also cause these issues. In fact, it could even pose a higher risk, according to Dr. Guo. Because the juice usually comes from multiple grapefruits rather than just one, it actually contains more furanocoumarins, making the effect more potent, Dr. Guo explains. What’s more, it doesn’t take much to feel those effects. Even small amounts of grapefruit juice can have a measurable impact—say, 200 to 250 milliliters, or around half the size of a Poland Spring water bottle. Per Harvard Health, a single glass can reduce the amount of CYP3A4 enzyme by nearly 50%. (By comparison, you’d need to eat about one whole grapefruit to achieve that drop.) “So that could potentially mess with the effectiveness of the drugs,” Van Eck says. Wiki Hover CUSTOMER SERVICE +1 (8O5)-3O1 7O71 Wiki Hover PHONE NUMBER +1 (8O5)-3O1 7O71 Wiki Hover CUSTOMER SERVICE +1 (8O5)-3O1 7O71 Wiki Hover PHONE NUMBER +1 (8O5)-3O1 7O71 If you’re not sure whether a specific food or beverage contains actual grapefruit or grapefruit juice (rather than, say, artificial flavoring), take a look at the ingredients list on the packaging, according to Dr. Guo. Do other types of fruit interact with meds too? Grapefruit is definitely the most prominent example, but some other types of citrus fruit can mess with meds in your body as well, according to Dr. Guo. These include the bitter orange (a.k.a. the Seville orange), which is often found in marmalade; the pomelo, which is native to Asia and has been nicknamed the “Chinese grapefruit”; and the tangelo, a cross between tangerines and grapefruit. Like grapefruit, all of these contain furanocoumarins, so they can have the same effects on medication.
